granisetron-hydrochloride and Grepafloxacin Interactions

Interactions between granisetron-hydrochloride(granisetron) and Grepafloxacin (grepafloxacin)

granisetron and grepafloxacin (Moderate Drug-Drug)

MONITOR: Based on in vitro inhibition data, coadministration with grepafloxacin may increase the plasma concentrations of drugs that are substrates of the CYP450 3A4 isoenzyme. The mechanism is decreased clearance due to inhibition of CYP450 3A4 activity by grepafloxacin.

MANAGEMENT: Caution is advised if grepafloxacin must be used concurrently with medications that undergo metabolism by CYP450 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever grepafloxacin is added to or withdrawn from therapy.