Interactions between glyburide(glyBURIDE) and Alcohol (ethanol)
glyBURIDE and ethanol (Moderate Drug-Drug)
GENERALLY AVOID: Alcohol may cause hypoglycemia or hyperglycemia in patients with diabetes. Hypoglycemia most frequently occurs with chronic drinking of large amounts of alcohol; however, it may also occur after binge drinking or moderate drinking, especially when the alcohol is ingested on an empty stomach. The mechanism is inhibition of gluconeogenesis and inhibition of the counterregulatory response to hypoglycemia. Hypoglycemia may last for 8 to 12 hours after ethanol ingestion. Chronic alcohol abuse may cause impaired glucose tolerance and hyperglycemia. Moderate alcohol consumption generally does not affect blood glucose levels in patients with well-controlled diabetes. In addition, a disulfiram-like reaction (flushing, headache, and nausea) has been reported frequently with chlorpropamide and very rarely with other sulfonylureas.
MANAGEMENT: Patients with diabetes should avoid alcohol if they experience flushing, headache, or nausea after alcohol ingestion, if their blood glucose is not well controlled, or if they have hypertriglyceridemia, neuropathy, or pancreatitis. Patients with well-controlled diabetes should limit their intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz. wine, 12 oz. beer, or 1.5 oz. distilled spirits) in addition to their meal plan. The alcohol should be consumed with a meal.
