Drug interactions between Gesticare DHA and mycophenolate mofetil
| Results for the following 2 drugs: |
|---|
| Gesticare DHA (multivitamin, prenatal) |
| mycophenolate mofetil |
Interactions between your selected drugs
multivitamin, prenatal ↔ mycophenolate mofetil
Applies to:Gesticare DHA (multivitamin, prenatal) and mycophenolate mofetil
ADJUST DOSING INTERVAL: Iron preparations may decrease the plasma concentrations of mycophenolic acid when coadministered orally. The mechanism is most likely due to formation of a drug-iron complex in the gastrointestinal tract, resulting in impaired absorption of mycophenolic acid. In a randomized, crossover study consisting of seven healthy subjects, a single dose of sustained-release iron (given as two 525 mg tablets of ferrous sulfate, equivalent to 210 mg of elemental iron) decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of mycophenolic acid (from four 250 mg capsules of mycophenolate mofetil) by 94% and 91%, respectively, compared to administration of mycophenolate mofetil alone.
MANAGEMENT: Patients requiring concomitant therapy with oral mycophenolic acid and iron or iron-containing supplements should separate the administration times of the medications by at least two hours. In addition, immediate-release iron products may be preferable to sustained-release formulations to minimize the likelihood of an interaction.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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