gallium-nitrate and Tobramycin Interactions

Interactions between gallium-nitrate(gallium nitrate) and Tobramycin (tobramycin)

tobramycin and gallium nitrate (Major Drug-Drug)

CONTRAINDICATED: Concomitant use of gallium nitrate and aminoglycosides may increase the risk that severe renal insufficiency will develop in patients with hypercalcemia of malignancy.

MANAGEMENT: Adequate hydration and close monitoring of renal function are recommended. The manufacturer recommends discontinuing gallium nitrate before starting therapy with other nephrotoxic agents.