fungizone and Ganite Interactions

Interactions between fungizone(amphotericin B) and Ganite (gallium nitrate)

amphotericin B and gallium nitrate (Major Drug-Drug)

CONTRAINDICATED: Concomitant use of gallium nitrate and amphotericin B may increase the risk that severe renal insufficiency will develop in patients with hypercalcemia of malignancy.

MANAGEMENT: Adequate hydration and close monitoring of renal function are recommended. The manufacturer recommends discontinuing gallium nitrate before starting therapy with other nephrotoxic agents.