Drug interactions between Fortovase and Prezista
Results for the following 2 drugs: |
|
|---|---|
| Fortovase (saquinavir) | |
| Prezista (darunavir) | |
Interactions between your selected drugs
saquinavir ⇔ darunavir
Applies to: Fortovase (saquinavir) and Prezista (darunavir)
GENERALLY AVOID: Coadministration with saquinavir may decrease the plasma concentrations of darunavir, even in the presence of low-dose ritonavir as a pharmacokinetic booster. The mechanism of interaction has not been described. In 14 study subjects, administration of darunavir/ritonavir (400 mg/100 mg twice a day) with saquinavir (hard gel capsule 1000 mg twice a day) decreased the peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough plasma concentration (Cmin) of darunavir by 17%, 26% and 42%, respectively, compared to administration without saquinavir. No statistically significant changes were reported for saquinavir Cmax, AUC, and Cmin during coadministration with darunavir/ritonavir compared to administration of saquinavir with ritonavir alone (1000 mg/100 mg twice a day).
MANAGEMENT: The appropriate dosage of darunavir when prescribed in combination with saquinavir has not been established. Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, the use of darunavir with saquinavir is not recommended, with or without low-dose ritonavir.
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