Drug interactions between Fortovase and Fuzeon
| Results for the following 2 drugs: |
|---|
| Fortovase (saquinavir) |
| Fuzeon (enfuvirtide) |
Interactions between your selected drugs
saquinavir ↔ enfuvirtide
Applies to:Fortovase (saquinavir) and Fuzeon (enfuvirtide)
Coadministration with ritonavir and/or saquinavir may slightly increase the plasma concentrations of enfuvirtide. The mechanism of interaction is unknown. According to the manufacturer, ritonavir (200 mg every 12 hours for 4 days) increased the steady-state peak plasma concentration (Cmax), area under the concentration-time curve (AUC) and trough concentration (Cmin) of enfuvirtide (90 mg twice a day) by 24%, 22% and 14%, respectively, in 12 HIV-positive subjects. Saquinavir-ritonavir (1000 mg-100 mg every 12 hours for 4 days) increased enfuvirtide AUC by 14% and Cmin by 26% but did not affect Cmax. These alterations are not considered to be clinically significant.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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