Drug interactions between Folex PFS and Neoral
Results for the following 2 drugs: |
|
|---|---|
| Folex PFS (methotrexate) | |
| Neoral (cyclosporine) | |
Interactions between your selected drugs
methotrexate ⇔ cyclosporine
Applies to: Folex PFS (methotrexate) and Neoral (cyclosporine)
MONITOR: Concomitant administration of cyclosporine and methotrexate may be associated with an increased risk of toxicity. In rheumatoid arthritis patients (n=20), the concentrations of methotrexate were increased by 30% and concentrations of the 7-hydroxy metabolite decreased by 80%. There was no significant change in cyclosporine concentrations (n=6). The mechanism is unknown.
MANAGEMENT: Close monitoring of cyclosporine and methotrexate concentrations, renal function, and liver enzymes is recommended during concurrent therapy. Dosage adjustments may be necessary. Patients should be advised to report any nausea, vomiting, mouth sores, diarrhea, abdominal pain, dizziness, fatigue, or headache.
See also...
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. Multum's drug information does not endorse drugs, diagnose patients, or recommend therapy. Multum's drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2009 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
