Drug interactions between Folex PFS and Imuran
Results for the following 2 drugs: |
|
|---|---|
| Folex PFS (methotrexate) | |
| Imuran (azathioprine) | |
Interactions between your selected drugs
azathioprine ⇔ methotrexate
Applies to: Imuran (azathioprine) and Folex PFS (methotrexate)
Methotrexate inhibits the hepatic metabolism of the thiopurines. Decreased first-pass metabolism and increased bioavailability result. The clinical significance of this interaction has not been determined and is probably insignificant with standard intermittent oral doses of methotrexate. Generally the combination has beneficial effects when used in the treatment of acute lymphoblastic leukemia.
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