flutamide and Miradon Interactions

Interactions between flutamide and Miradon (anisindione)

flutamide and anisindione (Moderate Drug-Drug)

MONITOR: Flutamide may enhance the hypoprothrombinemic response to warfarin by an unknown mechanism. In patients stabilized on warfarin, elevations in prothrombin time have been reported with the addition of flutamide to the drug regimen.

MANAGEMENT: Patients should be monitored for altered anticoagulation and advised to report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, nosebleeds, bleeding of gums from brushing, bruising, red or brown urine, or red or black stools.