Drug interactions between fluoxetine and Tegretol XR
Results for the following 2 drugs: |
|
|---|---|
| fluoxetine | |
| Tegretol XR (carbamazepine) | |
Interactions between your selected drugs
carbamazepine ⇔ fluoxetine
Applies to: Tegretol XR (carbamazepine) and fluoxetine
MONITOR: Fluoxetine may inhibit the hepatic metabolism of carbamazepine. Carbamazepine toxicity is possible. Data have been conflicting and one study has reported no significant pharmacokinetic interaction. A case of toxic serotonin syndrome has occurred in one patient who was taking both carbamazepine and fluoxetine.
MANAGEMENT: Until more information is available, close observation for clinical and laboratory evidence of carbamazepine toxicity is recommended. Dose adjustments may be required. Patients should be advised to report possible symptoms of carbamazepine toxicity (nausea, visual disturbances, dizziness, or ataxia) or serotonin syndrome (uncontrollable shivering, agitation, incoordination, restlessness, involuntary movements, hyperreflexia, and hyperarousal).
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