femtrace and Dantrolene Interactions

Interactions between femtrace(estradiol) and Dantrolene (dantrolene)

estradiol and dantrolene (Major Drug-Drug)

MONITOR CLOSELY: The use of estrogens may potentiate the risk of hepatotoxicity associated with dantrolene therapy. The mechanism of interaction is unknown. Fatal and non-fatal liver disorders of an idiosyncratic or hypersensitivity nature have been reported during dantrolene use. Although a definite drug interaction with estrogen therapy has not yet been established, hepatotoxicity has occurred more often in women over 35 years of age receiving concomitant estrogen therapy than in other patients treated with dantrolene.

MANAGEMENT: Dantrolene should be used with caution in patients, particularly females over 35 years of age, who are receiving concomitant estrogen therapy. Liver function tests (SGOT, SGPT, alkaline phosphatase, total bilirubin) should be performed prior to and during dantrolene therapy at appropriate intervals, and the drug should generally be withheld if significant abnormalities are observed. Patients treated with dantrolene should be advised to promptly contact their physician if they develop signs and symptoms of hepatocellular injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. The drug should be discontinued if hepatitis is suspected, since early detection and drug withdrawal will increase the likelihood of reversing the damage. Following resolution of clinical and laboratory abnormalities, reinstitution of dantrolene therapy should be attempted with extreme caution and only if benefit clearly outweighs the risk.