felbamate and Abraxane Interactions

Interactions between felbamate and Abraxane (paclitaxel protein-bound)

felbamate and paclitaxel protein-bound (Moderate Drug-Drug)

MONITOR: Theoretically, coadministration with drugs that are inducers of CYP450 2C8 and/or 3A4 may decrease the plasma concentrations of paclitaxel, which is metabolized by these isoenzymes.

MANAGEMENT: Clinicians should recognize the potential for interaction with drugs that induce CYP450 2C8 and/or 3A4 and monitor for evidence of reduced therapeutic response to paclitaxel during coadministration.