famotidine and Ketoconazole Interactions

Interactions between famotidine and Ketoconazole (ketoconazole)

ketoconazole and famotidine (Moderate Drug-Drug)

GENERALLY AVOID: H2 antagonists may reduce the bioavailability of ketoconazole by 75% to 80% resulting in decreased plasma ketoconazole concentrations and possible therapeutic failure. The mechanism is related to an increase in gastric pH and a decrease in absorption of the antifungal agent.

MANAGEMENT: Concomitant use is not recommended. Fluconazole absorption is not significantly affected.