famotidine and Itraconazole Interactions

Interactions between famotidine and Itraconazole (itraconazole)

itraconazole and famotidine (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Oral H2 antagonists may significantly decrease the plasma concentration of oral itraconazole. The mechanism is related to an increase in gastric pH resulting in a decrease in absorption of the antifungal. Clinical monitoring of patient response is recommended.

MANAGEMENT: H2 antagonists should be taken at least 2 hours after itraconazole. If necessary, an acidic pH may be produced by administration with an acidic beverage such as Coca-Cola(R) or Pepsi(R). However, clinicians should still consider the possibility of a reduced or subtherapeutic antifungal effect. It may be appropriate to switch to an agent like fluconazole or terbinafine whose absorption is not affected by stomach pH.