exubera and Alupent Interactions

Interactions between exubera(insulin inhalation, rapid acting) and Alupent (metaproterenol)

metaproterenol and insulin inhalation, rapid acting (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Bronchodilators and other orally inhaled products may alter the absorption of inhaled human insulin. In non-diabetic subjects with mild asthma (n=36) and moderate asthma (n=31), administration of albuterol 30 minutes prior to inhaled human insulin resulted in a mean increase in insulin systemic exposure (AUC) and peak plasma concentration (Cmax) of 25% to 50% compared to administration of inhaled human insulin alone.

MONITOR: Systemic administration or systemic absorption of orally inhaled corticosteroids and sympathomimetic amines (bronchodilators) may result in diminished efficacy of insulin. These drugs may interfere with blood glucose control because they can cause hyperglycemia, glucose intolerance, new-onset diabetes mellitus, and/or exacerbation of preexisting diabetes.

MANAGEMENT: Consistent timing of dosing of other inhaled products relative to inhaled human insulin administration is recommended. Blood glucose should be monitored closely, and the insulin dose adjusted accordingly.