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etopophos and vincasar-pfs Interactions

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You searched for interactions between:

  • etopophos
  • vincasar-pfs (vinCRIStine)

Interaction(s) found:

Minor Drug-Drug Interaction vinCRIStine and etoposide phosphate (Minor Drug-Drug)

Concurrent administration of vincristine and etoposide may lead to an earlier onset and/or an increased severity of side effects. The mechanism of action is inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and etoposide are used concomitantly, caution and close observation are advised.

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