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etopophos and sandimmune Interactions

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You searched for interactions between:

  • etopophos
  • sandimmune (cycloSPORINE)

Interaction(s) found:

Moderate Drug-Drug Interaction cycloSPORINE and etoposide phosphate (Moderate Drug-Drug)

ADJUST DOSE: High-dose cyclosporine (concentration greater than 2,000 ng/mL) has been shown to significantly increase systemic etoposide exposure and leukopenia. The mechanism is believed to be inhibition of the multidrug transporter P-glycoprotein in normal tissues.

MANAGEMENT: In combination with high-dose cyclosporine, etoposide dosage may be reduced by 50%. Complete blood counts should be monitored.

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