etopophos and nilotinib Interactions

You searched for interactions between:

• etopophos
• nilotinib

Interaction(s) found:

nilotinib and etoposide phosphate (Moderate Drug-Drug)

MONITOR: Based on in vitro inhibition data, coadministration with nilotinib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein efflux transporter and/or the CYP450 2D6, CYP450 3A4, or UGT1A1 isoenzymes. The mechanism is decreased clearance via these routes due to inhibition by nilotinib.

MANAGEMENT: Caution is advised if nilotinib must be used concurrently with medications that are substrates of the P-glycoprotein efflux transporter and/or the CYP450 2D6, CYP450 3A4, or UGT1A1 isoenzymes, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever nilotinib is added to or withdrawn from therapy.