etopophos and mibefradil Interactions

You searched for interactions between:

• etopophos
• mibefradil

Interaction(s) found:

mibefradil and etoposide phosphate (Moderate Drug-Drug)

MONITOR: Based on in vitro inhibition data, coadministration with mibefradil may increase the plasma concentrations of drugs that are substrates of CYP450 2D6 and/or 3A4. The mechanism is decreased clearance due to inhibition of these isoenzymes by mibefradil.

MANAGEMENT: Caution is advised if mibefradil must be used concomitantly with medications that undergo metabolism by CYP450 2D6 and/or 3A4, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever mibefradil is added to or withdrawn from therapy.