etopophos and mepron Interactions

You searched for interactions between:

• etopophos
• mepron (atovaquone)

Interaction(s) found:

atovaquone and etoposide phosphate (Moderate Drug-Drug)

MONITOR: The coadministration with atovaquone may modestly increase the plasma concentrations of etoposide and its catechol metabolite. The mechanism of interaction is unknown. In nine children treated with etoposide (300 mg/m2 intravenous infusion), atovaquone (45 mg/kg/day in 2 divided doses) increased the area under the plasma concentration-time curve (AUC) of etoposide and its catechol metabolite by a median of 8.6% and 28.4%, respectively, compared to administration following daily sulfamethoxazole-trimethoprim.

MANAGEMENT: Given the risk of etoposide-related secondary acute myeloid leukemia associated with minor changes in schedule and concurrent therapy, caution is advised during the simultaneous administration of atovaquone and etoposide. Patients should be monitored for etoposide toxicity such as myelosuppression.