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etopophos and fazaclo Interactions

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You searched for interactions between:

  • etopophos
  • fazaclo (cloZAPine)

Interaction(s) found:

Major Drug-Drug Interaction cloZAPine and etoposide phosphate (Major Drug-Drug)

CONTRAINDICATED: The use of clozapine with other potentially myelotoxic agents may increase the risk and/or severity of hematologic toxicity. Clozapine alone is associated with a significant risk of agranulocytosis, defined as an absolute neutrophil count (ANC) of less than 500/mm3. During premarketing trials in the U.S., at a time when the need for close monitoring of white blood cell counts was already recognized, the cumulative incidence of agranulocytosis at one year was estimated to be approximately 1.3%. The incidence has decreased postmarketing under a weekly WBC count monitoring system. Although the mechanism of clozapine-induced agranulocytosis is unknown, it is possible that causative factors may interact synergistically to increase the risk and/or severity of bone marrow suppression. A fatality rate of 3% has been reported for agranulocytosis associated with clozapine.

MANAGEMENT: The use of clozapine in combination with other agents having a well-known potential to cause agranulocytosis or otherwise suppress bone marrow function is considered contraindicated. Agents that may be significantly myelotoxic include antineoplastic drugs, some anticonvulsant and antirheumatic medications, albendazole, chloramphenicol, colchicine, dapsone, interferons, linezolid, pentamidine, procainamide, and zidovudine.

(web4)