Drug interactions between erythromycin/sulfisoxazole and Flonase
| Results for the following 2 drugs: |
|---|
| erythromycin/sulfisoxazole |
| Flonase (fluticasone nasal) |
Interactions between your selected drugs
erythromycin ↔ fluticasone
Applies to:erythromycin/sulfisoxazole and Flonase (fluticasone nasal)
Coadministration with erythromycin, a moderately potent CYP450 3A4 inhibitor, does not appear to significantly alter the systemic exposure to fluticasone following intranasal administration or oral inhalation. Fluticasone undergoes extensive first-pass and systemic metabolism via hepatic and intestinal CYP450 3A4, and inhibition of the isoenzyme by potent inhibitors such as ritonavir and ketoconazole has been shown to increase systemic bioavailability of the drug. However, a clinically significant interaction with erythromycin has not been reported. In a multiple-dose drug interaction study, coadministration of fluticasone nasal spray twice daily and erythromycin 500 mg twice daily did not affect fluticasone levels, but reduced plasma cortisol levels by 2%. Similary, coadministration of orally inhaled fluticasone propionate (500 mcg twice daily) and erythromycin (333 mg three times daily) did not affect fluticasone propionate pharmacokinetics. No particular precaution should be necessary during concomitant use.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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