erlotinib and Basaljel Interactions

Interactions between erlotinib and Basaljel (aluminum carbonate)

aluminum carbonate and erlotinib (Moderate Drug-Drug)

ADJUST DOSING INTERVAL: Concurrent administration of antacids or other agents with acid-neutralizing effects may decrease the oral bioavailability of erlotinib and reduce its concentrations in plasma. The solubility of erlotinib decreases when the pH is over 5, resulting in reduced absorption. The clinical significance is unknown.

MANAGEMENT: If concurrent use cannot be avoided, antacids should be administered least 4 hours before or 2 hours after the daily dose of erlotinib.