Drug interactions between Equetro and Invega
Results for the following 2 drugs: |
|
|---|---|
| Equetro (carbamazepine) | |
| Invega (paliperidone) | |
Interactions between your selected drugs
carbamazepine ⇔ paliperidone
Applies to: Equetro (carbamazepine) and Invega (paliperidone)
MONITOR: The concomitant use of potent inducers of P-glycoprotein efflux transporters such as carbamazepine may reduce plasma concentrations of paliperidone and its efficacy. The proposed mechanism is induction of renal P-glycoprotein. Average maximum plasma concentrations (Cmax) and AUC of paliperidone decreased by 37% and the renal clearance increased by 35% during concurrent administration of carbamazepine 200 mg twice a day. Larger doses may result in larger reductions in paliperidone plasma levels. PGP induction may take 2 to 3 weeks to reach steady state after a PGP-inducing drug is initiated, and as long to wear off after the inducer is discontinued. Other PGP inducers such as rifampin and St. John's wort may also interact, although clinical data have not been reported.
MANAGEMENT: Patients should be monitored for signs of reduced efficacy during concomitant use and for 2 to 3 weeks after a PGP-inducing drug is added, discontinued, or its dose is changed. Dose adjustments of paliperidone may be required.
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