Drug interactions between Emblon and Miradon
| Results for the following 2 drugs: |
|---|
| Emblon (tamoxifen) |
| Miradon (anisindione) |
Interactions between your selected drugs
tamoxifen ↔ anisindione
Applies to:Emblon (tamoxifen) and Miradon (anisindione)
CONTRAINDICATED: Tamoxifen may enhance the hypoprothrombinemic response to warfarin. Response to other anticoagulants may be affected as well. The mechanism is unknown but may be due to competition for the same metabolic pathways. Severe and/or fatal hemorrhages have been reported with concomitant use of coumarin derivatives. A similar interaction may occur with toremifene and other triphenylethylene antiestrogens.
MANAGEMENT: When used to reduce the incidence of breast cancer in high-risk women, tamoxifen is considered contraindicated in patients requiring concomitant coumarin anticoagulants. Other patients should be closely monitored for excessive anticoagulation and prolonged prothrombin times. Patients should be advised to notify their physicians if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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