Drug interactions between Eltroxin and indinavir
| Results for the following 2 drugs: |
|---|
| Eltroxin (levothyroxine) |
| indinavir |
Interactions between your selected drugs
levothyroxine ↔ indinavir
Applies to:Eltroxin (levothyroxine) and indinavir
MONITOR: A single case report suggests that indinavir may increase serum thyroxine concentrations, potentially resulting in hyperthyroidism. The proposed mechanism is indinavir inhibition of glucuronosyltransferase, which is partially responsible for the metabolic clearance of thyroxine. The case report describes an HIV-infected patient who had been stabilized on levothyroxine 0.75 mg/day for several years when treatment with stavudine, lamivudine, and indinavir was begun. Approximately 50 days later, she presented with nervousness, palpitations, restlessness, weakness, and slight weight loss. Thyroid function testing revealed suppression of thyroid-stimulating hormone (TSH less than 0.1 mIU/L), increased free T4 (57 pmol/L), and increased free T3 (33 pmol/L). Thyroid function returned to normal one month after the levothyroxine dose was reduced to 0.12 mg/day.
MANAGEMENT: During coadministration with indinavir, the possibility of an enhanced therapeutic response to levothyroxine should be considered. Dosage adjustment as well as clinical and laboratory monitoring may be appropriate whenever indinavir is added to or withdrawn from therapy.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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