Drug interactions between Eltroxin and Evista
Results for the following 2 drugs: |
|
|---|---|
| Eltroxin (levothyroxine) | |
| Evista (raloxifene) | |
Interactions between your selected drugs
levothyroxine ⇔ raloxifene
Applies to: Eltroxin (levothyroxine) and Evista (raloxifene)
MONITOR: An isolated case report suggests that concurrent administration of raloxifene may interfere with the gastrointestinal absorption of levothyroxine. The mechanism of interaction is unknown. A 79-year-old woman stabilized on levothyroxine 0.15 mg/day for several years experienced symptoms of hypothyroidism with an elevated thyroid-stimulating hormone (TSH) level 2 to 3 months after initiating therapy with raloxifene 60 mg/day. The levothyroxine dosage was gradually increased to 0.3 mg/day over the next several months but TSH level remained elevated nine months after starting raloxifene. To test the possibility of an interaction, administration times of the drugs were separated by approximately 12 hours on two separate occasions lasting 6 to 8 weeks each. In addition, the absorption of 1.0 mg of levothyroxine sodium with and without the coadministration of raloxifene was measured on two occasions by collecting serial blood samples for 6 hours. Results of the studies support the speculation that raloxifene reduced the absorption of levothyroxine in the patient. MANAGEMENT: Pharmacologic response and serum TSH level should be monitored more closely following the addition of raloxifene to a stable levothyroxine regimen. Patients should consider separating the times of administration as much as possible if an interaction is suspected.
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