Drug interactions between Eldepryl and Sinemet
Results for the following 2 drugs: |
|
|---|---|
| Eldepryl (selegiline) | |
| Sinemet (carbidopa/levodopa) | |
Interactions between your selected drugs
levodopa ⇔ selegiline
Applies to: Sinemet (carbidopa/levodopa) and Eldepryl (selegiline)
ADJUST DOSE: When used as an adjunct to levodopa/carbidopa in the treatment of Parkinson's disease, selegiline may enhance levodopa-associated side effects in some patients. The presumed mechanism is enhanced peripheral catecholamine availability due to decreased degradation (MAOI activity) and increased synthesis (levodopa effect) of dopamine and, probably, norepinephrine. The concomitant administration of carbidopa has been reported to prevent or blunt the hypertensive response by inhibiting peripheral conversion of levodopa to dopamine.
MANAGEMENT: Two to three days after adding selegiline to the regimen, the levodopa/carbidopa dosage may require reduction by 10 to 30%. Due to the risks of nonselective MAO inhibition and drug interactions, selegiline doses should not exceed 10 mg/day.
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