efavirenz and Midazolam Interactions

Interactions between efavirenz and Midazolam (midazolam)

midazolam and efavirenz (Major Drug-Drug)

CONTRAINDICATED: Efavirenz may interfere with the metabolism of benzodiazepines. The mechanism is competitive inhibition of the CYP450 3A4 enzyme. The accumulation of benzodiazepines, especially midazolam and triazolam is associated with potentially serious and/or life-threatening events (e.g., prolonged sedation, respiratory depression).

MANAGEMENT: Midazolam or triazolam should not be administered concurrently with efavirenz.