Drug interactions between Edecrin and Zelapar
Results for the following 2 drugs: |
|
|---|---|
| Edecrin (ethacrynic acid) | |
| Zelapar (selegiline) | |
Interactions between your selected drugs
ethacrynic acid ⇔ selegiline
Applies to: Edecrin (ethacrynic acid) and Zelapar (selegiline)
Monoamine oxidase inhibitors (MAOIs) may theoretically potentiate the hypotensive effect of some medications. This effect may stem from a gradual MAOI-induced accumulation of false neurotransmitters in peripheral adrenergic neurons that have minimal activity at alpha- and beta-adrenergic receptors, resulting in a functional block of sympathetic neurotransmission. Indeed, MAOIs alone quite commonly produce orthostatic hypotension. In addition, bradycardia has been reported with the concomitant use of beta blockers and MAOIs. The clinical significance of these effects is unknown. If these drugs are coadministered, patients should be monitored for evidence of an interaction (e.g., hypotension, orthostasis, bradycardia, tachycardia, dizziness, or syncope).
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