echinacea and Aceon Interactions

Interactions between echinacea and Aceon (perindopril)

echinacea and perindopril (Moderate Drug-Drug)

MONITOR: Concomitant use of echinacea with other agents known to induce hepatotoxicity may increase the risk of liver injury. Use of echinacea beyond eight weeks may have adverse effects on the liver, although the magnitude of its hepatotoxic potential is unclear.

MANAGEMENT: Until more information is available, caution is recommended if echinacea is used chronically in combination with other potentially hepatotoxic agents (e.g., alcohol; androgens and anabolic steroids; antituberculous agents; azole antifungal agents; ACE inhibitors; endothelin receptor antagonists; interferons; nucleoside reverse transcriptase inhibitors; thiazolidinediones; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, HMG-CoA reductase inhibitors, and niacin; other herbal products such as kava). Patients should be advised to notify their doctor if they experience signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice.