e-400-clear and Anisindione Interactions

Interactions between e-400-clear(vitamin E) and Anisindione (anisindione)

vitamin E and anisindione (Moderate Drug-Drug)

MONITOR: Vitamin E may potentiate the effects of warfarin and other related anticoagulants and increase the risk of bleeding. Vitamin E is thought to inhibit the oxidation of reduced vitamin K and interfere with the functions of vitamin K-dependent clotting factors. Although conflicting information exists regarding the effect of vitamin E on coagulation, available data suggest a potential interaction with oral anticoagulants at vitamin E dosages exceeding 400 international units per day.

MANAGEMENT: The INR should be monitored closely and anticoagulant dosage adjusted accordingly during concomitant therapy, particularly following initiation or discontinuation of vitamin E therapy in patients who are stabilized on an oral anticoagulant. Patients should be advised to notify their physicians if they experience any signs of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.