Drug interactions between dyphylline/guaifenesin and febuxostat
| Results for the following 2 drugs: |
|---|
| dyphylline/guaifenesin |
| febuxostat |
Interactions between your selected drugs
dyphylline ↔ febuxostat
Applies to:dyphylline/guaifenesin and febuxostat
MONITOR: Coadministration with febuxostat may alter the pharmacokinetics of theophylline. The proposed mechanism is inhibition of xanthine oxidase by febuxostat. In healthy volunteers, administration of theophylline in combination with febuxostat 80 mg once daily resulted in a 6% increase in theophylline peak plasma concentration (Cmax) and a 6.5% increase in systemic exposure (AUC). These changes were not considered statistically or clinically significant. However, the study also showed an approximately 400-fold increase in the urinary excretion of 1-methylxanthine, one of the major theophylline metabolites. The safety of long-term exposure to 1-methylxanthine has not been evaluated.
MANAGEMENT: No dosage adjustment is necessary for theophylline when coadministered with febuxostat, but caution is advised. Because the safety of long-term exposure to 1-methylxanthine is unknown, this should be taken into consideration when deciding to use the combination.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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