Drug interactions between doxorubicin and Oncovin
Results for the following 2 drugs: |
|
|---|---|
| doxorubicin | |
| Oncovin (vincristine) | |
Interactions between your selected drugs
doxorubicin ⇔ vincristine
Applies to: doxorubicin and Oncovin (vincristine)
Concurrent administration of vincristine and doxorubicin may lead to an earlier onset and/or an increased severity of side effects. The mechanism of action is the inhibition of the metabolism of both drugs by a hepatic cytochrome P-450 isoenzyme in the CYP 3A subfamily. The clinical significance of this interaction has not been established. If vincristine and doxorubicin are used concomitantly, caution and close observation are advised.
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