Drug interactions between divalproex sodium and Nexium
| Results for the following 2 drugs: |
|---|
| divalproex sodium |
| Nexium (esomeprazole) |
Interactions between your selected drugs
divalproex sodium ↔ esomeprazole
Applies to:divalproex sodium and Nexium (esomeprazole)
The coadministration of esomeprazole and drugs that are substrates of the CYP450 2C19 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to competitive inhibition of CYP450 2C19 activity by esomeprazole. The clinical significance of this potential interaction, if any, is unknown. Caution is advised if esomeprazole is used concomitantly with medications that undergo metabolism by CYP450 2C19, particularly those with a narrow therapeutic range.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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