Drug interactions between Diuretic Ap-Es and tolterodine
Results for the following 2 drugs: |
|
|---|---|
| Diuretic Ap-Es (hydralazine/hydrochlorothiazide/reserpine) | |
| tolterodine | |
Interactions between your selected drugs
hydrochlorothiazide ⇔ tolterodine
Applies to: Diuretic Ap-Es (hydralazine/hydrochlorothiazide/reserpine) and tolterodine
Anticholinergic agents may increase the absorption and oral bioavailability of thiazide diuretics. The proposed mechanism involves increased gastrointestinal transit time due to reduction of stomach and intestinal motility by anticholinergic agents. In six healthy volunteers, pretreatment with propantheline prolonged the time to reach peak plasma concentration (Tmax) for hydrochlorothiazide from 2.4 to 4.8 hours and increased its total 48-hour urinary recovery by 36%. Similar results were reported for chlorothiazide in another study. The clinical significance of these changes is unknown.
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