Drug interactions between Diltia XT and VESIcare
Results for the following 2 drugs: |
|
|---|---|
| Diltia XT (diltiazem) | |
| VESIcare (solifenacin) | |
Interactions between your selected drugs
diltiazem ⇔ solifenacin
Applies to: Diltia XT (diltiazem) and VESIcare (solifenacin)
MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of solifenacin, which has been shown to be a substrate of the isoenzyme in vitro. According to the product labeling, coadministration of solifenacin (10 mg) with the potent CYP450 3A4 inhibitor ketoconazole (400 mg) resulted in a 1.5-fold increase in the mean solifenacin peak plasma concentration (Cmax) and a 2.7-fold increase in the systemic exposure (AUC) compared to administration of solifenacin alone.
MANAGEMENT: Pharmacologic response to solifenacin should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the solifenacin dosage adjusted if necessary. Patients should be advised to contact their physician if they experience undue adverse effects of solifenacin such as severe abdominal pain or constipation for 3 or more days.
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