Drug interactions between Dilantin and Vibramycin
Results for the following 2 drugs: |
|
|---|---|
| Dilantin (phenytoin) | |
| Vibramycin (doxycycline) | |
Interactions between your selected drugs
doxycycline ⇔ phenytoin
Applies to: Vibramycin (doxycycline) and Dilantin (phenytoin)
MONITOR: Phenytoin (and other hydantoins) may significantly decrease doxycycline half-life resulting in decreased antimicrobial effectiveness. The mechanism may be related to induction of doxycycline metabolism.
MANAGEMENT: Patients should be monitored for altered doxycycline efficacy. It may be necessary to increase doxycycline dosage. Alternative antimicrobial therapy with a different tetracycline or a different class of antimicrobial agent may be preferable.
See also...
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