Drug interactions between Dilantin and nitrofurantoin
Results for the following 2 drugs: |
|
|---|---|
| Dilantin (phenytoin) | |
| nitrofurantoin | |
Interactions between your selected drugs
nitrofurantoin ⇔ phenytoin
Applies to: nitrofurantoin and Dilantin (phenytoin)
MONITOR: One patient experienced seizures and a drop in phenytoin levels while taking concurrent nitrofurantoin. Phenytoin levels rose when nitrofurantoin was discontinued. The mechanism is unknown but may be related to induction of hepatic metabolism by nitrofurantoin. A similar reaction may occur with other hydantoins.
MANAGEMENT: Phenytoin serum concentrations should be monitored during coadministration of these agents. Patients should be advised to promptly report loss of seizure control to their caregiver.
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