Drug interactions between Dilantin and disulfiram
| Results for the following 2 drugs: |
|---|
| Dilantin (phenytoin) |
| disulfiram |
Interactions between your selected drugs
phenytoin ↔ disulfiram
Applies to:Dilantin (phenytoin) and disulfiram
MONITOR: Phenytoin serum levels may increase significantly in the presence of disulfiram. Rapid increases in serum phenytoin levels of 73% to 500% have been reported. Disulfiram may inhibit hepatic microsomal metabolism of phenytoin and decrease its elimination rate. Theoretically, other hydantoins may be similarly affected.
MANAGEMENT: Patients should be closely observed for signs of hydantoin toxicity if these drugs must be given concurrently and serum phenytoin concentrations should be monitored. Patients should be advised to notify their physician if they experience symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. The hydantoin dose may need to be decreased.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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