Drug interactions between Diflucan and Norvir
Results for the following 2 drugs: |
|
|---|---|
| Diflucan (fluconazole) | |
| Norvir (ritonavir) | |
Interactions between your selected drugs
fluconazole ⇔ ritonavir
Applies to: Diflucan (fluconazole) and Norvir (ritonavir)
The coadministration with fluconazole may slightly increase the plasma concentrations of ritonavir. The proposed mechanism is fluconazole inhibition of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of ritonavir. In an open-label, randomized, crossover study consisting of eight healthy subjects, fluconazole (400 mg on day 1, 200 mg on days 2 to 5) increased the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of ritonavir (200 mg every 6 hours for 4 days) by approximately 15% and 12%, respectively, compared to when ritonavir was administered alone. In a study of 3 HIV-infected patients treated with ritonavir 600 mg orally twice a day, there were no detectable changes in the pharmacokinetics of ritonavir following addition of fluconazole. Other azole antifungal agents are expected to affect ritonavir in a similar fashion but possibly to a greater extent, since fluconazole is a relatively weak inhibitor of CYP450 3A4. No special precautions are necessary when fluconazole is given with ritonavir.
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