Drug interactions between diazepam and Nexium
Results for the following 2 drugs: |
|
|---|---|
| diazepam | |
| Nexium (esomeprazole) | |
Interactions between your selected drugs
diazepam ⇔ esomeprazole
Applies to: diazepam and Nexium (esomeprazole)
The coadministration of esomeprazole and diazepam may result in elevated plasma concentrations of the latter. The mechanism is decreased clearance of diazepam due to competitive inhibition of CYP450 2C19 activity by esomeprazole. The manufacturer reports a 45% decrease in clearance, although increased plasma levels of diazepam were observed only from 12 hours after dosing and onwards, at which time the plasma levels were below the therapeutic interval. No particular action or caution is required, as this interaction is unlikely to be of clinical significance.
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