Drug interactions between diazepam and Nexium
| Results for the following 2 drugs: |
|---|
| diazepam |
| Nexium (esomeprazole) |
Interactions between your selected drugs
diazepam ↔ esomeprazole
Applies to:diazepam and Nexium (esomeprazole)
The coadministration of esomeprazole and diazepam may result in elevated plasma concentrations of the latter. The mechanism is decreased clearance of diazepam due to competitive inhibition of CYP450 2C19 activity by esomeprazole. The manufacturer reports a 45% decrease in clearance, although increased plasma levels of diazepam were observed only from 12 hours after dosing and onwards, at which time the plasma levels were below the therapeutic interval. No particular action or caution is required, as this interaction is unlikely to be of clinical significance.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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