Drug interactions between Diastat Pediatric and Inderide
| Results for the following 2 drugs: |
|---|
| Diastat Pediatric (diazepam) |
| Inderide (hydrochlorothiazide/propranolol) |
Interactions between your selected drugs
diazepam ↔ hydrochlorothiazide
Applies to:Diastat Pediatric (diazepam) and Inderide (hydrochlorothiazide/propranolol)
MONITOR: Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
MANAGEMENT: Caution is advised during coadministration of these agents. Close monitoring for development of hypotension is recommended. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia.
propranolol ↔ diazepam
Applies to:Inderide (hydrochlorothiazide/propranolol) and Diastat Pediatric (diazepam)
The pharmacologic effects of some benzodiazepines may be increased by some beta-blockers. Propranolol and metoprolol may inhibit the hepatic metabolism of diazepam and other mechanisms may also be involved. Most changes have been clinically insignificant; however, increased reaction times and/or decreased kinetic visual acuity have been reported with some combinations. Observation for altered benzodiazepine effects is recommended if these drugs must be used together. Patients should be warned against driving or operating hazardous machinery.
See also...
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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