Drug interactions between dextromethorphan/quinidine and Inderide
| Results for the following 2 drugs: |
|---|
| dextromethorphan/quinidine |
| Inderide (hydrochlorothiazide/propranolol) |
Interactions between your selected drugs
quinidine ↔ propranolol
Applies to:dextromethorphan/quinidine and Inderide (hydrochlorothiazide/propranolol)
MONITOR: Quinidine may increase serum levels of some oral beta-blockers. The proposed mechanism is inhibition of CYP450 2D6 first-pass metabolism and decreased hepatic clearance of hepatically metabolized beta-blockers. Quinidine and beta-blockers may also have additive negative inotropic effects, which can be beneficial when used to treat atrial fibrillation. However, adverse effects have been reported with quinidine and propranolol.
MANAGEMENT: Patients should be monitored for orthostatic hypotension, cardiac arrhythmias, bradycardia, and heart failure, and beta-blocker dosage should be decreased if necessary.
See also...
- Dextromethorphan/quinidine Drug Interactions
- dextromethorphan and quinidine General Consumer Information
Drug Interaction Classification
The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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