desferal and Ascot Interactions

Interactions between desferal(deferoxamine) and Ascot (ascorbic acid)

ascorbic acid and deferoxamine (Moderate Drug-Drug)

ADJUST DOSE: Although ascorbic acid is commonly given during deferoxamine treatment, cardiac disorders (left ventricular dysfunction) and cataracts have been reported with high doses (more than 200 mg/day) or long-term use. Higher doses of vitamin C do not provide any additional benefit. The mechanism is unknown.

MANAGEMENT: Ascorbic acid should not be initiated until after the first month of treatment with deferoxamine. Doses should be given on the same days that deferoxamine is administered. Doses should not exceed 200 mg per day (in divided doses) for adults, 50 mg per day for children younger than 10 years, and 100 mg per day for children over 10 years. Cardiac function should be monitored during concomitant use.