Depakote-er Drug Interactions

Depakote-er (divalproex sodium) is known to interact with the following drugs:

Click on a link below to view Drug-Drug Interactions with Depakote-er (divalproex sodium).

Major Interactions
Darvon, Darvon-N, Doribax, doripenem, ertapenem, GHB, imipenem, Invanz, Lamictal, Lamictal Blue, Lamictal CD, Lamictal Green, Lamictal Orange, lamotrigine, meropenem, Merrem, Merrem Novaplus, PP-Cap, propoxyphene, propoxyphene hydrochloride, propoxyphene napsylate, sodium oxybate, sodium phenylacetate, vorinostat, Xyrem, Zolinza

Moderate Interactions
40 Winks, Abilify, Abilify Discmelt, acetylcarbromal, Acetylsalicylic Acid, Actidose-Aqua, Actidose-Aqua Advance, Actiq, Activated Charcoal, Activated Charcoal with Sorbitol (obsolete), Active Carbon, Acuprin 81, Adapin, Adgan, Adgyn Estro, Aerodiol, AHist, alcohol, alcohol, ethyl, Aler-Dryl, Aler-Tab, Alfenta, alfentanil, All Day Allergy, Aller-Chlor, Allergia-C, Allerhist-1, Allermax, Alora, Alphagan, Alphagan P, alprazolam, alprazolam extended release, Altaryl, Ambien, Ambien CR, Amen, Amigesic, amitriptyline, amobarbital, amoxapine, Amrix, Amytal Sodium, Anaflex, Anafranil, Anergan 50, anisindione, Antiflex, Antinaus 50, APO-Go, APO-Go Pen, Apokyn, apomorphine, apraclonidine ophthalmic, Aptivus, Aquachloral Supprettes, Aquest, Arava, Argesic-SA, aripiprazole, Arthritis Pain, Arthropan, ASA, Ascriptin Enteric, Asendin, Aspergum Cherry, Aspergum Orginal, Aspir-Low, aspirin, aspirin extended release, Aspirin Lite Coat, Aspirin Litecoat, Aspirin Low Strength, Aspirtab, Astramorph PF, Atarax, Ativan, Aventyl HCl, Avinza, Avonex, Avonex Prefilled Syringe, Aygestin, azatadine, AZT, B-Vex, baclofen, Banaril, Banflex, Banophen, Bayer Aspirin, Bayer Aspirin Regimen, Bayer Aspirin Sugar Free, Bayer Aspirin with Calcium, Bayer Childrens Aspirin, Bayer Low Strength, Bayer Plus, Bayer Select Backache Pain Formula, Bedol, Beldin, Belix, Ben-Tann, Benadryl, Benadryl Allergy, Benadryl Child Dye Free, Benadryl Childrens Allergy Fastmelt, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Benahist-10, Benahist-50, Benoject-50, Benzacot, benztropine, Betaseron, Biaxin, Biaxin XL, Biaxin XL-Pak, Bidhist, Bismarex, Bismatrol, Bismatrol Maximum Strength, bismuth subsalicylate, brimonidine ophthalmic, Bromaphen, bromocriptine, brompheniramine, brompheniramine extended release, BroveX, BroveX CT, Buffered Aspirin, Bufferin, Bufferin Arthritis Strength, Bufferin Extra Strength, Buffex, Buprenex, buprenorphine, Busodium, BuSpar, BuSpar Dividose, busPIRone, butabarbital, butalbital, Butisol Sodium, butorphanol, Bydramine, C.P.M., Calm-Aid, Camila, Carbacot, carbamazepine, carbamazepine extended release, Carbatrol, carbetapentane, carbinoxamine, carbinoxamine extended release, Carbinoxamine PD, Carbomix, Carbosorb X, Carboxine, carisoprodol, Catapres, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3, Cenestin, Cerebyx, Cesamet, cetirizine, Char-Flo with Sorbitol (obsolete), Charcoaid, Charcoaid 2000, Charcoaid-G, charcoal, Charcoal Plus DS, Charcocaps, Charcodote, Charcodote (obsolete), Charcotabs, Charcotrace, Chem Mart Nasal Decongestant Capsule, Chem Mart Tramadol, Childrens Kaopectate, Chlo-Amine, Chlor-Al Rel, Chlor-Mal, Chlor-Phen, Chlor-Phenit, Chlor-Trimeton, Chlor-Trimeton Allergy SR, chloral hydrate, chlordiazepoxide, chlormezanone, chlorotrianisene, Chlorphen, chlorphenesin, chlorpheniramine, Chlorpheniramine (Allergy), chlorpheniramine 24 hour extended release, chlorpheniramine extended release, chlorproMAZINE, chlorproMAZINE extended release, ChlorTan, chlorzoxazone, cholestyramine, Cholestyramine Light, choline salicylate, cisplatin, clarithromycin, clarithromycin extended release, clemastine, Climara, Climaval, Climodien, Clinagen LA 40, clofarabine, Clolar, clomiPRAMINE, clonazepam, clonidine, clonidine topical, clorazepate, clorazepate extended release, codeine, codeine phosphate, codeine sulfate, Codimal A, Cogentin, Comfort Pac with Cyclobenzaprine, Compazine, Compazine Spansule, Compoz Nighttime Sleep Aid, Compro, Comtan, conjugated estrogens, conjugated estrogens synthetic A, conjugated estrogens synthetic B, conjugated estrogens topical, Contac 12 Hour Allergy, Cophene B, Cordron NR, Coumadin, Crinone, Curretab, cyclizine, cyclobenzaprine, cyclobenzaprine extended release, Cyclogest, Cycrin, Cylert, Cymbalta, cyproheptadine, Dailyhist-1, Dalgan, Dalmane, Dantrium, Dantrium Intravenous, dantrolene, Dazidox, Dehydrated Alcohol, Delestrogen, DELIDOSE, Delta-Lutin, Demerol HCl, Dep Gynogen, Depo-Estradiol, Depo-Provera, Depo-Provera Contraceptive, depo-subQ provera 104, DepoDur, Depogen, Dermestril, Dermestril - Septem, DERMESTRIL SEPTEM, desipramine, desogestrel, desvenlafaxine, Desyrel, Desyrel Dividose, dexbrompheniramine, dexmedetomidine, dezocine, Di-Phen, Diastat, Diastat AcuDial, Diastat Pediatric, diazepam, dicumarol, dienestrol topical, diethylstilbestrol, diflunisal, dihydrocodeine, Dilantin, Dilantin Infatabs, Dilantin Kapseals, Dilantin-125, Dilaudid, Dilaudid-5, Dilaudid-HP, Dimetane, Dimetane Extentab, Dimetapp Allergy, Dimetapp Allergy Liquigel, Dioval 40, Dioval XX, Diphedryl, Diphen, Diphen AF, Diphen Cough, Diphenadryl, Diphendryl, Diphenhist, diphenhydrAMINE, diphenhydrAMINE citrate, diphenhydrAMINE tannate, Diphenmax, Diphenydramine Quick Melt, Diphenyl, Diphenylin, Diprivan, Disalcid, Diskets, Divigel 0.25 mg/packet, Divigel 0.5 mg/packet, Divigel 1 mg/packet, Dizac, Doans Pills, Doans Pills Extra Strength, Dolobid, Dolophine, Doloral, Doloral Sirop, Doral, doxepin, doxepin topical, doxylamine, DPH, Dromadol SR, Dromadol XL, dronabinol, droperidol, drospirenone, duloxetine, Dura-Estrin, Duraclon, Duragen, Duragesic, Duragesic-100, Duragesic-12, Duragesic-25, Duragesic-50, Duragesic-75, Duralutin, Duramorph PF, Dytan, Dytuss, E-Mycin, E.E.S. Granules, E.E.S.-200, E.E.S.-400, E.E.S.-400 Filmtab, Easprin, echinacea, Ecotrin, Ecotrin Adult Low Strength, Ecotrin Maximum Strength, Ed Chlor-Tan, Ed ChlorPed, Effexor, Effexor XR, Efidac-24 Chlorpheniramine, Elavil, Elestrin, Elleste Solo, Empirin, Endep, Endocodone, Endometrin, Enjuvia, entacapone, Entaprin, Entercote, Epitol, Equanil, Equetro, Errin, Ery-Tab, Eryc, EryPed, EryPed 200, EryPed 400, Erythrocin Lactobionate, Erythrocin Stearate Filmtab, Erythrocot, erythromycin, erythromycin base, erythromycin estolate, erythromycin ethylsuccinate, erythromycin lactobionate, erythromycin stearate, escitalopram, Esclim, Eskalith, Eskalith-CR, estazolam, esterified estrogens, Estinyl, Estra-C, Estra-V 40, Estrace, Estrace Vaginal Cream, Estraderm, Estraderm MX, Estraderm TTS, estradiol, estradiol acetate, estradiol benzoate, estradiol cypionate, ESTRADIOL G GAM, Estradiol Patch, estradiol topical, estradiol valerate, Estradot, Estradot 100, Estradot 37.5, Estradot 50, Estradot 75, Estragyn 5, Estragyn LA 5, ESTRAPATCH, Estrasorb, ESTREVA, Estring, Estro-A, Estro-Cyp, Estro-L.A., Estro-Span 40, Estrofem, Estrogel, estrone, Estrone AQ, estropipate, estropipate topical, eszopiclone, ETH-Oxydose, ethanol, ethinyl estradiol, ethotoin, Ethyl Alcohol, ethynodiol, etonogestrel, etravirine, Eucarbon, Evamist, Evorel, Extra Strength Bayer, EZChar, Eze D.S., Fasprin, felbamate, Felbatol, Fematrix, Fempatch, Femring, FEMSEPT, FemSeven, FemSeven Sequi Phase I, FemTab, Femtrace, Femtran, fentanyl, fentanyl topical, Fentora, Fexmid, First Progesterone MC10, First Progesterone MC5, FIRST-Progesterone VGS 100, FIRST-Progesterone VGS 200, FIRST-Progesterone VGS 25, FIRST-Progesterone VGS 400, FIRST-Progesterone VGS 50, flavoxate, Flexeril, Flexoject, Flexon, fluphenazine, fluphenazine decanoate, fluphenazine enanthate, fluphenazine hydrochloride, flurazepam, fluvoxamine, fluvoxamine extended release, Folex PFS, fosphenytoin, Fosrenol, Genacote, Genahist, Gennin-FC, Genprin, GenRx Tramadol, Geodon, Gestone, Gynodiol, Gynogen LA 20, halazepam, Halcion, Haldol, Haldol Decanoate, Halfprin, haloperidol, haloperidol decanoate, Healthstream Activated Charcoal, Histaject, Histex CT, Histex I/E, Histex PD, Histex Pd 12, Hydramine, Hydramine Compound, Hydramine Cough Syrup, hydrocodone, Hydromorph Contin, hydromorphone, hydromorphone extended release, Hydrostat IR, hydroxyprogesterone, hydrOXYzine, hydrOXYzine hydrochloride, hydrOXYzine pamoate, Hylutin, hypericum perforatum, Hyprogesterone, Hyrexin, Hyzine, Ilosone, Ilotycin Gluceptate, imipramine, imipramine pamoate, Implanon, Inapsine, Infumorph, INH, Insta-Char, Intelence, interferon beta-1a, interferon beta-1b, Invega, Ionsys, Iopidine, isocarboxazid, isoniazid, J-Tan, J-Tan PD, J.L. Bragg's Medicinal Charcoal, Jantoven, Jolivette, K-Pek, Kadian, Kao-Tin Bismuth Subsalicylate Formula, Kaopectate, Kaopectate Anti-Diarrheal Upset Stomach Reliever, Kaopectate Extra Strength, Kapectolin (New Formula), Karbons, Kestrone 5, Ketalar, ketamine, Klonopin, Klonopin Wafer, lanthanum carbonate, Larapam SR, Largon, Lariam, leflunomide, Levo-Dromoran, levocetirizine, levomethadyl acetate, levonorgestrel, levorphanol, LEVRIX, Lexapro, Librium, Lioresal, Lioresal Intrathecal, Liqui-Char, Liqui-Char with Sorbitol (obsolete), Litecoat Aspirin, lithium, lithium carbonate, lithium carbonate extended release, lithium citrate, Lithobid, Lithonate, Lithotabs, Lodrane 12 Hour, Lodrane 24, Lodrane XR, lorazepam, Low Dose ASA, loxapine, Loxitane, Loxitane C, Loxitane IM, Ludiomil, Luminal, Lunesta, Luvox, Luvox CR, Lyrica, M-Eslon, M-Oxy, M. O. S., Maalox Total Stomach Relief, Magan, magnesium salicylate, Maolate, maprotiline, Marezine, Marinol, Marplan, Marthritic, Maximum Strength Stress, MB-TAB, Medicoal, Medidiol 10, medroxyPROGESTERone, mefloquine, Megace, Megace ES, megestrol, Mellaril, Mellaril-S, Menaval-20, Menest, Menopause Formula Progesterone, MENOREST, Menorest Patch, Menostar, meperidine, mephenytoin, meprobamate, Meridia, Mesantoin, mesoridazine, mestranol, metaxalone, methadone, Methadose, methocarbamol, methotrexate, Methotrexate Sodium, Preservative Free, metoclopramide, midazolam, Miltown, Minitabs, Mio-Rel, Miradon, Mirapex, Mirena, mirtazapine, Mitran, Moban, Mobidin, molindone, Mono-Gesic, morphine, morphine 24 hour extended release, morphine extended release, Morphine IR, morphine liposomal, Morphine LP Epidural, morphine preservative-free, Morphine Rapi-Ject, Morphitec, MS, MS Contin, MS/S, MSIR, MST, MY-E, Myolin, Mysoline, nabilone, nalbuphine, naltrexone, Nardil, Nasahist B, Navane, ND-Stat, nefazodone, Nembutal, Nembutal Sodium, Nervine, Neupro, Nightime Sleepaid, Niravam, Nor-QD, Nora-Be, norelgestromin, norethindrone, norethindrone acetate, norethindrone topical, Norflex, Norflex Injectable, norgestimate, norgestrel, Norit, Norplant System, Norpramin, nortriptyline, Norwich Aspirin, Nu-Med, Nubain, Numorphan HCl, Nuprin Backache Caplet, Nuvelle TS Phase I, Nydrazid, Nytol Caplet, Nytol Maximum Strength, Oesclim, Oestradiol, Oestradiol Implants, OESTRODOSE, OESTROGEL, Oestrogel Pump-Pack, Ogen 0.625, Ogen 1.25, Ogen 2.5, Ogen Vaginal Cream, olanzapine, olopatadine nasal, OMS, Opana, Opana ER, opium, Opium Deodorized, Optimine, Optimum Charcoal, Oramorph SR, Orap, Orfro, Organon Oestradiol, Orion Progesterone, Orlaam, Ormazine, OROMONE, orphenadrine, orphenadrine extended release, Orphenate, Ortho Dienestrol, Ortho Micronor, Ortho-Est, Ovrette, oxazepam, oxycodone, oxycodone extended release, OxyContin, Oxyfast, OxyIR, oxymorphone, oxymorphone extended release, P-Tann, P-Tex, Palgic, paliperidone, Palladone, Palladone SR, Pamelor, Paraflex, Parafon Forte DSC, Paral, paraldehyde, Pardryl, Paregoric, Parlodel, Parnate, paroxetine, paroxetine extended release, paroxetine mesylate, Patanase, Paxarel, Paxil, Paxil CR, PBZ, PBZ-SR, PCE Dispertab, PediaTan, Pediatex, Pediatex 12, Pediox, Pediox-S, Peganone, pemoline, Pentazine, pentazocine, pentobarbital, Peptic Relief, Pepto-Bismol, Pepto-Bismol Maximum Strength, Percolone, pergolide, Periactin, Permax, Permitil, perphenazine, Pexeva, Pharmacia Carbosorb, phenacemide, Phenadoz, Phenazine 50, phenelzine, Phenergan, Phenergan Fortis, phenobarbital, Phenoject-50, Phenurone, phenyl salicylate, Phenytek, phenytoin, phenytoin extended release, Phenytoin Sodium, Prompt, pimozide, Pink Bismuth, Plan B, Platinol (Restricted Access), Platinol-AQ, pramipexole, Precedex, pregabalin, Premarin, Premarin Intravenous, Premarin Vaginal, Prevalite, Prialt, primidone, Primogyn Depot, Pristiq, Pro-Med, Prochieve, prochlorperazine, prochlorperazine extended release, Procot, Prodrox, Progest, Progestasert System, progesterone, progesterone topical, Progynova, Progynova TS, Prolixin, Prolixin Decanoate, Prolixin Enanthate, Promacot, promazine, promethazine, Promethegan, Prometrium, Prop-A-Tane, propiomazine, propofol, Prorex, Prosom, protriptyline, PROVAMES, Provera, Prudoxin, Q-Dryl, Q-Dryl A/F, QDALL AR, quazepam, Quenalin, Questran, Questran Light, quetiapine, quetiapine extended release, quinestrol, Rebif, Reglan, Relaxazone, Remeron, Remeron SolTab, remifentanil, Remular, Remular-S, Repreve, Requip, ReQuip Follow on Pack, Requip Starter Kit, ReQuip Starter Pack, Requip XL, Rescudose, Restoril, Retrovir, ReVia, Rexolate, Rezine, Rheumatrex Dose Pack, Ridramin, Rifadin, Rifadin IV, rifampin, Rimactane, Risperdal, Risperdal Consta, Risperdal M-Tab, risperidone, RMS, Robaxin, Robaxin-750, Robimycin, Rohist, ropinirole, ropinirole extended release, rotigotine, Roxanol, Roxanol 100, Roxanol-T, Roxicodone, Roxicodone Intensol, Salflex, salicylamide, salsalate, Salsitab, Sandrena, Scot-Tussin Allergy Relief Formula, secobarbital, Seconal Sodium, Serax, Serentil, Seroquel, Seroquel XR, sertraline, Serzone, sibutramine, Siladryl, Siladryl Allergy, Siladryl DAS, Siladyl SA, Silphen Cough, Siltane, Simply Sleep, Sinequan, Skelaxin, Skelex, Sleep Tab II, Sleep Tabs, Sleep-ettes, Sleep-ettes D, Sleep-Eze-3, Sleepinal, Sloprin, sodium salicylate, sodium thiosalicylate, Solfoton, solotuss, Soma, Sominex, Sominex Maximum Strength Caplet, Somnicaps, Somnote, Sonata, Sparine, St. John's wort, St. Joseph Aspirin, St. Joseph Aspirin Adult Chewable, St. Joseph Aspirin Adult EC, Stadol, Stadol NS, Stanback Analgesic, Statex, Stelazine, Stilphostrol, Stress Maximum Strength, Strifon Fort, Sublimaze, Subutex, Sufenta, sufentanil, Surmontil, SYSTEN, Tace, Talwin Lactate, Tanacof-XR, TanaHist-PD, Tao, Tasmar, Tavist, Tavist Allergy, Tavist-1, Tegretol, Tegretol XR, Temaril, temazepam, Terry White Chemists Tramadol, THAIS, THAISSEPT, thalidomide, Thalomid, Theraflu Thin Strips Multi Symptom, Therapy Bayer, thioguanine, thioridazine, thiothixene, Thorazine, Ticon, Tigan, tipranavir, tizanidine, Tofranil, Tofranil-PM, tolcapone, Topamax, Topamax Sprinkle, topiramate, Total Allergy, traMADOL, traMADOL extended release, Tramahexal, Tramahexal SR, Tramake, Tramake Insts, Tramal, Tramal SR, Tramedo, Trancopal, Tranxene SD, Tranxene T-Tab, tranylcypromine, traZODONE, Trexall, Tri-Buffered Aspirin, Triaminic Allergy, Triaminic Thin Strips Cough & Runny Nose, triazolam, trifluoperazine, triflupromazine, Trilafon, trimeprazine, trimethobenzamide, trimipramine, tripelennamine, Tripohist, triprolidine, triprolidine extended release, troleandomycin, Truxadryl, Tusal, Tusstat, Twilite, Ultiva, Ultram, Ultram ER, Uni-Tann, Unisom, Unisom Sleepgels Maximum Strength, Uprima, Urispas, V-Gan-25, V-Gan-50, Vagifem, Valergen, Valium, Valrelease, Valu-Dryl, Vanadom, Vanatrip, VaZol, venlafaxine, venlafaxine extended release, Versed, Vistacon, Vistacot, Vistaject-50, Vistaril, Vistaril IM, Vistazine, Vistazine 50, Vivactil, Vivelle, Vivelle-Dot, VIVELLEDOT, Vivitrol, Wal-finate, warfarin, Xanax, Xanax XR, Xyzal, XYZALL, YSP Aspirin, zaleplon, Zamadol, Zamadol 24hr, Zamadol Melt, Zamadol SR, Zanaflex, Zero-Order Release, Zetran, ziconotide, zidovudine, ziprasidone, Zoloft, zolpidem, zolpidem extended release, Zonalon, Zorprin, Zumenon, Zydol, Zydol SR, Zydol XL, Zymine, Zymine XR, Zyprexa, Zyprexa Zydis, Zyrtec, Zyrtec Hives

Minor Interactions
Acid Relief, Alka-Mints, Alkets, Alkums, Aloh-Gel, Alternagel, Alu-Cap, Alu-Tab, aluminum carbonate, aluminum hydroxide, Amilac, Amitone, Amphojel, Basaljel, bortezomib, Cal Oys, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Calcitab, calcium carbonate, Calcium Concentrate, Calcium Liquid Softgel, Calcium Oyster, Calcium Oyster Shell, Caltrate, Caltro, Chooz, cimetidine, Citra pH, Citrate-Phos-Dex, Clopine, clozapine, Clozapine Synthon, Clozaril, Concentrated Phillips Milk of Magnesia, Denzapine, Dewees Carminative, Dialume, Dicarbosil, dihydroxyaluminum sodium carbonate, Equilet, esomeprazole, ethosuximide, evening primrose, Evening Primrose Oil, Ex-Lax Milk of Magnesia, Extra Strength Mylanta Calci Tabs, FazaClo, fluoxetine, fluoxetine extended release, Gabitril, gingko, gingko biloba, ginkgo, ginkgo biloba, Icar Prenatal Chewable Calcium, Losospan, Lowsium, Maalox Antacid Barrier, Maalox Childrens', Maalox Quick Dissolve, Maalox Quick Dissolve Extra Strength, Maalox Quick Dissolve Maximum Strength, Maalox Regular Strength, Mag-200, Mag-Carb, Mag-Ox 400, magaldrate, MagGel, magnesium carbonate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, Maoson, Mg hydroxide, Mg oxide, Milk of Magnesia, Mylanta Child, Nephro Calci, Nexium, Nexium I.V., nimodipine, Nimotop, Orinase, Os-Cal, Os-Cal 500, oxcarbazepine, Oysco 500, Oyst Cal, Oyst Cal 500, Oyster, Oyster Cal, Oyster Cal 500, Oyster Calcium, Oyster Shell, oyster shell calcium, Oyster Shell Calcium 500, Pepto Children's, Phillips Milk of Magnesia, Phillips' Cramp-free, Primrose Oil, Prozac, Prozac Weekly, Rapiflux, Ri-Mag, Riopan, Rolaids Sodium Free, Rolaids Soft Chew, Ron Acid, Sarafem, Selfemra, sodium citrate, Super Calcium, Surpass, Surpass Extra Strength, Tagamet, Tagamet HB, tiagabine, Titralac, Tol-Tab, TOLBUTamide, Tricitrasol, Trileptal, Tums, Tums 500, Tums E-X, Tums Extra Strength, Tums Ultra, Ultra Mylanta Calci Tabs, Uro-Mag, Velcade, Zaponex, Zarontin

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