Drug interactions between Depakote ER and Nexium
Results for the following 2 drugs: |
|
|---|---|
| Depakote ER (divalproex sodium) | |
| Nexium (esomeprazole) | |
Interactions between your selected drugs
divalproex sodium ⇔ esomeprazole
Applies to: Depakote ER (divalproex sodium) and Nexium (esomeprazole)
The coadministration of esomeprazole and drugs that are substrates of the CYP450 2C19 enzymatic pathway may result in elevated plasma concentrations of those drugs. The mechanism is decreased clearance due to competitive inhibition of CYP450 2C19 activity by esomeprazole. The clinical significance of this potential interaction, if any, is unknown. Caution is advised if esomeprazole is used concomitantly with medications that undergo metabolism by CYP450 2C19, particularly those with a narrow therapeutic range.
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