Drug interactions between Depakote ER and isoniazid
Results for the following 2 drugs: |
|
|---|---|
| Depakote ER (divalproex sodium) | |
| isoniazid | |
Interactions between your selected drugs
isoniazid ⇔ divalproex sodium
Applies to: isoniazid and Depakote ER (divalproex sodium)
MONITOR: Several case reports suggest that combining valproic acid (or its derivatives) and isoniazid may increase the toxicity of both drugs. The mechanism, while not established, is probably inhibition by isoniazid of the hepatic metabolism of valproic acid. Case reports suggest that the risk of this interaction may be greater for slow acetylators of isoniazid.
MANAGEMENT: Valproic acid dosage may need to be reduced if isoniazid is added to the therapy. Additional monitoring for altered valproic acid response may be prudent when isoniazid therapy is started or stopped. Patients should be advised to notify their caregiver if they experience weakness, fatigue, confusion, ataxia, increased seizures, nausea, or vomiting during concomitant use.
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