Drug interactions between Depakene and phenobarbital
Results for the following 2 drugs: |
|
|---|---|
| Depakene (valproic acid) | |
| phenobarbital | |
Interactions between your selected drugs
valproic acid ⇔ phenobarbital
Applies to: Depakene (valproic acid) and phenobarbital
MONITOR: Valproate may increase plasma levels of phenobarbital. The mechanism may be related to decreased CYP450 hepatic metabolism of the barbiturate.
MANAGEMENT: Patients started on combination therapy should be closely monitored for clinical and laboratory evidence of toxicity. They should be advised to notify their physician if they experience excessive sedation or lethargy. Reductions in the phenobarbital dosage may be required.
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